The exposition of the museum reflects the theme of the study of Siberia (geographical study of the region, historical and ethnographic study of the region, natural science study of the region) and the role of Tobolsk. In the memorial office of A.A. Dunin-Gorkavich presents a unique collection of personal belongings of the scientist. The Gallery "Glorious names of the land of Tobolsk" introduces visitors to prominent Siberians.